Sizing duct by the velocity method
A duct is sized by the air it has to carry and the speed you are willing to move it at. Divide the airflow in cubic feet per minute by the velocity in feet per minute and you get the cross-section the duct needs in square feet. Multiply by 144 and you are in square inches, which is how duct actually gets talked about on site.
Velocity is the trade-off, and it is yours to set. Move the same air faster and the duct gets smaller, cheaper and louder. Slow it down and the duct grows, gets quieter, and takes more metal and more ceiling. Trunks, branches and returns are all run at different speeds and local practice varies, which is why this tool asks for the figure instead of choosing one for you.
Round and rectangular ducts are not the same just because the opening is the same size. A rectangle has more wall rubbing against the same air, so it behaves like a smaller pipe than its area suggests. That is what the "round duct this rectangle behaves like" figure is for, and this tool works it out with the standard equivalent-round formula. Compare fittings and friction charts against that figure, not against the diameter the area suggests.
The common mistake is flattening a duct to fit a joist bay and assuming area is all that matters. A 4 by 20 has the same cross-section as an 8 by 10 and a noticeably worse equivalent round. Give this tool the side your space forces and it will tell you what the other one has to be. Zeus keeps a price book that doubles as inventory, so the duct and fittings you settle on become priced lines instead of a size scribbled on a bulkhead.